TOP WHERE TO PHENOBARBITAL SECRETS

Watch Closely (1)phenobarbital will reduce the extent or impact of fentanyl transmucosal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Watch Intently. Coadministration of fentanyl with CYP3A4 inducers could lead to some lessen in fentanyl plasma concentrations, deficiency of efficacy or, quite possibly, enhancement of a w